Arrowhead Halts its ARO-ENaC Phase 1/2 Clinical Trial
Arrowhead Pharmaceuticals recently notified about its voluntary decision to put a pause on its ongoing Phase 1/2 clinical study of ARO-ENaC for patients with cystic fibrosis (CF). The announcement came after a preliminary update from an ongoing chronic toxicology study in rats that demonstrated some unexpected signals of local lung inflammation.
ARO-ENaC is an investigational RNA interference (RNAi) therapeutic drug, which was undergoing evaluation in a Phase 1/2 clinical trial (AROENaC1001) has now been put on hold with the stoppage on further patient screening, enrollment and dosing while ...