Central Nervous System

Spinal Muscular Atrophy (SMA) is a genetic disorder that affects the part of the nervous system which controls the voluntary movement of limbs and muscles. SMA results in the loss of motor neurons in the Spinal Cord. SMA is one of the most common causes of infant mortality and mobility impairment. Spinal Muscular Atrophy is caused by the mutations in chromosome 5 of the SMN1 gene. No- SMN1 Mutation and other mutations are also found to be responsible for the occurrence of Spinal Muscular Atrophy. Defect in the SMN gene further leads to the deficiency of SMA protein. There are multiple copies of SMA2 gene as well, but they aren’t as effective as SMN1 gene. The Spin...