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Notizia - Recent Pharma, Healthcare and Biotech Happenings

Biogen terminates ALS Pact with Karyopharm; AbbVie’s Immunological Drug Skyrizi; NICE Backs Astellas’ Oral Therapy Evrenzo; Roche’s Crenezumab Fails in Clinical Trial; FDA Grants Fast Track Designation to Dianhydrogalactitol; Sierra Oncology Submits NDA for Momelotinib

Biogen terminates USD 217 Million ALS Pact with Karyopharm Biogen has backed out of the four-year-old partnership with Karyopharm on a drug candidate for the neurological disease amyotrophic lateral sclerosis, which could have cost the US biotech up to USD 217 million. The 2018 agreement that granted Biogen rights to the oral selective inhibitor of nuclear export (SINE) compound KPT-350 included a USD 10 million upfront payment, but Karyopharm stated in a filing with the Securities and Exchange Commission that it will no longer be eligible for any of the program's USD 207 million in milestone payments. Biogen's BIIB100 drug is intended to lower inflammation and ...

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