IgA Nephropathy (IgAN): Pathogenesis and the Need for Targeted Therapies
IgA nephropathy is a complex autoimmune disorder characterized by the accumulation of galactose-deficient IgA1 antibodies in the glomeruli, triggering a cascade of immune responses that ultimately lead to chronic kidney damage. Driven by a multi-hit pathogenesis involving genetic predisposition, aberrant immune complex formation, and complement activation, the disease progresses silently until proteinuria and hematuria become clinically evident. Environmental triggers such as infections and hypertension further amplify renal injury, highlighting the need for early intervention. Despite advance...
