Neurology

Diverse voltage and ligand gated ion channels mediate Neuron excitation through various ions by sending electrical signals. Calcium is critical for cellular functioning. Voltage-gated calcium channels are primary mediators of depolarization-induced calcium entry into neurons. Calcium ions act as membrane potentiation and signal entities. Multiple genes for calcium channel a1 subunits, co-assembly with a variety of ancillary calcium channel subunits, and alternative splicing generate great diversity of calcium channel subtypes.  These channels fulfill highly specialized roles in specific neuronal subtypes at a particular subcellular loci. Under normal resting condi...