Eli Lilly secures conditional marketing authorisation for olaratumab injection with doxorubicin
The European Commission (EC) has granted conditional marketing authorization for Eli Lilly and Company’s olaratumab injection of 10mg/ml in combination with doxorubicin, to treat adults with advanced soft tissue sarcoma (STS) who are not suited for curative surgery or radiotherapy and were not previously treated with doxorubicin. Olaratumab is a recombinant, human immunoglobulin G subclass 1 (IgG1) monoclonal antibody. Data from the Phase II portion of the pivotal JGDG trial has paved the way for the conditional marketing authorization followed by a positive recommendation from the Committee for Medicinal Products for Human Use (CHMP).
Study reveals synthetic DNA vaccine approach successfully protects against Zika virus
A new research has indicated that a synthetic DNA vaccine approach has been able to successfully protect against infection, brain damage and death caused by the mosquito-borne Zika virus in-vivo. There are currently no licensed therapies or vaccines to protect against the Zika virus. In this preclinical study conducted by the Wistar Institute, all of the animal models were protected after vaccination followed by a challenge with the Zika virus. In addition, they were protected from degeneration in the cerebral cortex and hippocampal areas of the brain, while the other cohort showed the brain’s degeneration after Zika infection.
