AstraZeneca Ends eVOLVE-Lung02 Phase III Trial Evaluating Volrustomig Plus Chemotherapy
AstraZeneca has decided to discontinue the Phase III eVOLVE-Lung02 trial, which was assessing volrustomig in combination with chemotherapy as a first-line treatment for patients with metastatic non-small cell lung cancer (mNSCLC) and tumors expressing PD-L1 at less than 50%. The study compared this combination with pembrolizumab plus chemotherapy.
The decision follows a planned review of the trial data by the Independent Data Monitoring Committee (IDMC). Based on its assessment, the committee determined that the volrustomig-based regimen was unlikely to achieve either of the ...