Antibody-drug conjugate (ADCs) is a new emerging class of highly potent pharmaceutical drugs, which is a great combination of chemotherapy and immunotherapy. Over the past couple of decades, antibody-drug conjugates have revolutionized the field of cancer chemotherapy. ADCs are composed of 3 parts: an antibody drug, a cytotoxic payload, and a chemical linker protein to hold the 2 parts together.
ADCs payloads can be classified into two major types: (i) tubulin inhibitors inhibit tubulin polymerization and trigger cell cycle arrest in the G2/M phase and subsequent cell apoptosis; these inhibitors include monomethyl auristatin E (MMAE), monomethyl auristatin F (MMAF)...
