Lilly’s RET inhibitor Retevmo exhibits early promise in new cancer types
The phase 1/2 LIBRETTO-001 trial enrolled 32 patients with 12 unique RET fusion-positive advanced cancer types, comprising pancreatic, colon, breast and salivary cancer, with 62.5% affected by gastrointestinal tumours.
Across all 32 patients who administered Retevmo (selpercatinib), the researchers noticed a confirmed objective response rate (ORR) of 47%, with the median duration of response not yet reach with a follow-up of 13 months.
As per Lilly, responses were ongoing in 73% of responding patients in the study. David Hyman, chief medical officer, oncology at Lilly, said that these en...