Oncology

AstraZeneca recently has announced the results of the clinical trials POSEIDON which included the study of a combination of drugs Imfinzi (durvalumab) and tremelimumab with chemotherapy in lung cancer. Imfinzi is a human monoclonal antibody which blocks the interaction of PD-L1 with PD-1 by binding itself with the former. FDA approved the use of the drug in early for the treatment of unresectable stage III non-small cell lung cancer (NSCLC) and locally advanced or metastatic urothelial carcinoma. Tremelimumab, on the other hand, is a fully human monoclonal antibody which works against Cytotoxic T-cell lymphocyte-associated protein 4 (CTLA-4) and boosts the act...