Oncology

C-X-C chemokine receptors (CXCR) is a family of G protein-coupled receptors that comprises of a large subfamily of the rhodopsin superfamily of 7-transmembrane domain receptors. Two types of chemokine receptors have been identified including monogamous chemokine receptors (bind to only one specific chemokine) and promiscuous chemokine receptors (bind to more than a dozen chemokines). A total of seven C-X-C chemokine receptors are known from CXCR1 through to CXCR7 out of which CXCR 1, 2 and 4 inhibitors being the key CXCR inhibitors are being developed as potential drugs. The CXCR1 and 2 mediates the GPCR signaling pathways and cellular functions such as calcium release...