Histone deacetylase ( HDAC ) inhibitors are a new class of anti-cancer agents which play important roles in epigenetic or non-epigenetic regulation, including programmed cell death, and cell cycle arrest in cancer cells. Histone deacetylase inhibitors are either naturally occurring or they can be synthetically produced.
The HDAC inhibitors have been identified and further classified into four groups on the basis of their homology with yeast HDACs. Such inhibitors further induce different phenotypes in various transformed cells, including growth arrest, autophagic cell death or reactive oxygen species (ROS)-induced cell death. Histone deacetylase is an opposing class of...
