Toll-like receptors are a family of various related proteins that play a major role in the development and defense of plants and animals. These receptors were first discovered in Drosophila melanogaster in the late 20th century which later led to the identification of mammalian homologs. Human TLR family consists of 10 different receptors named TLR1-TLR10. TLRs are necessary for the recognition of microbes, and the subsequent development of host immunity against the pathogen.
However, TLRs have also been implicated in the development of various immune disorders. Overstimulation of innate immune cells and inflammatory factors mediated by TLR has been established to be t...
