Refractory chronic cough (RCC) is characterized by ongoing coughing that persists even after comprehensive evaluation and appropriate management of all identifiable underlying causes, pointing to an underlying neurogenic cough hypersensitivity. It is clinically distinct from other forms of chronic cough, and diagnosis is established by exclusion, using tools such as spirometry, FeNO testing, chest imaging, nasendoscopy, and reflux assessments to eliminate treatable drivers and confirm a persistent hypersensitivity-mediated cough.
More than 6 million RCC patients across the leading markets (the US, EU4, the UK, and Japan) were estimated in 2024 to have RCC lasting o...
