Cyclin-dependent kinase 7 (CDK7) belongs to the CDK family of serine/threonine protein kinases and plays a crucial role in regulating the cell cycle and mRNA transcription. It is often overexpressed in various cancers, making it a promising target for cancer treatment due to its involvement in both transcription and cell cycle regulation.
Additionally, CDK7 can directly influence the activities of the estrogen receptor, a key factor in breast cancer progression. While several CDK4/6 inhibitors are approved for use alongside endocrine therapies in treating ER+ breast cancer, resistance to these drugs is becoming a significant issue. Notably, breast cancer cell...
