Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of medications used to treat type 2 diabetes mellitus (T2DM) and obesity by lowering serum glucose levels and managing metabolism in affected patients. Companies are continuously striving to improve approved therapies and develop next-generation obesity treatments. These efforts include combining GLP-1 with other entero-pancreatic hormones that have complementary actions and synergistic potential, such as glucose-dependent insulinotropic polypeptide (GIP), glucagon, and amylin. These therapies are currently undergoing investigational trials aimed at enhancing the weight loss and cardiometabolic benefits of ...