Complement 3 glomerulopathy (C3G) is a form of glomerular disease where there’s a notable presence of C3 complement component deposits in the glomeruli. These deposits occur without significant amounts of immunoglobulin and without the deposition of C1q and C4. The buildup of C3, without much classical or lectin complement component, indicates a dysregulation of the alternative complement pathway as the primary mechanism. This particular observation, alongside the typical clinical features of glomerulonephritis but with minimal or no immunoglobulin deposits, serves as the key diagnostic criterion.
DelveInsight’s analysis reveals that the overall diagnosed pr...
