Alagille syndrome (ALGS), also referred to as Alagille–Watson syndrome, is a rare autosomal dominant condition. Mutation in JAG1 or NOTCH2 gene causes the condition to occur, but most of the individuals’ mutation in the JAG1 gene is noted. The symptoms vary in patients, and the severity of the disease ranges from mild to severe. The body’s multiple organ systems like heart, liver, kidneys, skeleton, and eyes can get affected. The characteristics include bile duct paucity, i.e., the number of bile ducts within the liver getting reduced, cholestasis, pruritis, jaundice, etc. The disease is rare, with a noted occurrence of 1 case in 30,000 children. According to the...
