Alnylam Pharmaceuticals has released the Phase III results of the clinical trial ILLUMINATE-A evaluating lumasiran for Primary Hyperoxaluria Type 1
Primary Hyperoxaluria Type 1 (PH1) is a rare disorder that affects kidneys due to an excess buildup of oxalate, which in normal cases is filtered through the kidneys and excreted in the urine.
Alnylam's Lumasiran is an experimental RNA interference (RNAi) therapy that targets hydroxy acid oxidase 1 (HAO1) responsible for the production of the glycolate oxidase (GO), thus blocking the production of oxalate. The drug was able to hit all the primary endpoints and secondary endpoints with no reported serious ...
