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Cell-Cell Interactions are essential for multiple biological processes to run smoothly, including a variety of processes like embryonic development, immunity, and neuronal signaling. Cell-cell interaction dynamics can be monitored in vivo by using intravital microscopy, but this approach does not provide any information regarding the ligands and receptors involved or enable the isolation of interacting cells for downstream analysis. Now a complementary approach has come into the scene that uses bacterial sortase A-mediated cell labeling across synapses of immune cells to identify receptor-ligand interactions between cells in living mice. It works by generatin...