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AACR 2022 KRAS

Snippets - A Small piece of News or Article

AACR 2022: Novartis shifting focus towards directly targeting KRASG12c after disappointment from SHP2 inhibitor, TNO155.

Post Lumakras ‘approval, Adagrasib’s PDUFA date, Novartis now ready to enter the KRASG12C space Novartis is now heading towards its unique KRASG12C inhibitor in patients with advanced non-small cell lung cancer (NSCLC). The company presented the promising preliminary data (Phase Ib) from the KontRASt-01 study evaluating JDQ443 in patients with advanced NSCLC. The results reported that at the median duration of 15.9 weeks, the confirmed overall response rate (ORR) at RP2D 200 mg was 57%, which somehow demonstrated the early efficacy signals and a tolerable safety profile from the dose-escalation portion of the Phase Ib/II KontRASt-01 trial. In terms of a safety poi...

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