Gene therapy

Feb 26, 2021

CNS disorders are a wide-ranging set of disorders in which the brain loses its normal functioning, limiting everyday ability to function. These may arise from various reasons-some are inherited, some result from damage, and some from infections. It contributes to the highest disability-adjusted life years. The curr...

Jan 19, 2021

Biohaven's Troriluzole Dwindles Again In Alzheimer’s After Anxiety  Biohaven Pharmaceuticals had put too much faith in its third-generation prodrug, Troriluzole. The company has tested the efficacy of the drug in more than one indication, including generalized anxiety disorder (GAD), obsessive-compulsive di...

Jan 12, 2021

Medivir, IGM Biosciences enters into an exclusive licensing agreement for Birinapant Medivir AB has entered into an exclusive licensing agreement with IGM Biosciences to receive global, exclusive development rights for Birinapant. Birinapant is a clinical-stage SMAC mimetic that degrades Inhibitors of Apoptosis ...

Aug 20, 2020

FDA rejects BioMarin's gene therapy and Gilead's filgotinib over concerns The FDA refused to approve BioMarin's hemophilia A gene therapy valoctocogene roxaparvovec. The U.S. regulator that had earlier told there was no requirement of an AdComm for the drug, aka, valrox, has issued a complete response (CRL) lett...

Mar 04, 2020

Cocaine- a stimulant- made from the most addictive plant - cocoa plant, is known as the most addictive substance known to be existing on the Earth, hence is abused the most. As per the annual report titled ‘Key Substance Use and Mental Health Indicators in the United States’ presented by the National Survey on Drug...

Jan 20, 2020

HIV infection has become a global health burden, has claimed over 32 million lives so far since the very first case of AIDS was reported in 1981. According to a report put forward by the WHO, HIV prevalence was reported to be around 37.9million by the end of 2018.  However, HIV has grown to pandemic proport...

Dec 20, 2019

A human body comprises of many small, long, narrow and broad blood vessels that carry oxygenated blood from the heart to other body parts for their normal functioning. However, due to life style-shifting more towards a sedentary one, and inculcation of bad food habits, there has been an increase in the number of no...

Nov 28, 2019

Sanofi’s Toujeo has received FDA recommendation for its expanded use in Type 1 Diabetes. Toujeo is an insulin glargine injection to control the highs and lows of blood sugar in the body. Indicated to be used in adults and paediatric patients of age six and older. Earlier, the injection was considered suitab...

Nov 25, 2019

Beta thalassemia, globally affects almost 288,000 people, with an incidence of 60,000 cases every year. A rare monogenic genetic disease, beta-thalassemia is caused by more than 200 mutations of the beta-globin gene (HBB). The Beta-thalassemia pharmacological treatment mainly comprises of regular blood-transfus...

May 27, 2019

The U.S. FDA recently approved the much talked about Novartis’s drug Zolgensma for treating a life-threatening condition Spinal Muscular Atrophy (SMA).  SMA is a neuromuscular disorder that worsens the muscles over time. It happens due to a mutation in the SMN1 gene that results in the deficiency of an SMN pro...