HIF-expressing cancers
Apr 19, 2017
The Snippet: Targeting metabolism in Renal Cell Carcinoma
Loss of VHL and elevated expression of HIF transcription factors leads to reprogramming of tumour cell metabolism, enabling renal cell carcinoma (RCC) cells to use carbons from glutamine-derived aspartate to drive pyrimidine biosynthesis. Now, researchers show that inhibition of glutamine availability decreases aspa...
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