Isocitrate dehydrogenase inhibitors
Sep 22, 2017
Isocitrate dehydrogenase (IDH) inhibitors– Emerging Anti-Cancer Therapeutics
The enzyme, isocitrate dehydrogenase (IDH) catalyzes the oxidative decarboxylation of isocitrate, producing alpha-ketoglutarate and CO2. It is found in the cytosol, mitochondrial matrix, and peroxisomes. IDH is responsible for cellular respiration in the TCA cycle. Isocitrate dehydrogenase exists in three isoforms i...
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