JAK inhibitors

Oct 25, 2024

Exosome therapies represent an exciting frontier in the development of novel treatments for a wide range of diseases. The ability to harness the natural communication system of cells offers unparalleled potential for precise and effective treatments. While challenges remain, ongoing research and technological advan...

Jun 10, 2024

Myelofibrosis is a rare disease with a high unmet need, with no disease-modifying treatments. Before 2011, treatment options for myelofibrosis were limited to either allogeneic transplant or palliation. Currently, Janus kinase (JAK) inhibitors have become the mainstay of pharmacologic therapy for myelofibrosis pati...

Jul 09, 2021

JAK inhibitors also termed “Jakinibs,” work by inhibiting the activity and response of one or more Janus kinase enzymes. These inhibitors function against the Janus kinases, a group of four proteins that includes JAK1, JAK2, JAK3, and tyrosine kinase 2 (TYK2). These proteins control inflammation by triggering intra...

Apr 05, 2021

Autoimmune and inflammatory diseases are common with a diverse array. Different organs are affected, and significant variability is seen among the individuals when talking about the severity, or the response to the treatment. Deregulated cytokine activity has a vital role in explaining autoimmune disease patho...

Oct 17, 2016

Janus Kinase (JAK) inhibitors are the ones that inhibit the functional activity of enzymes that belong to Janus Kinase family such as JAK1, JAK2, JAK3 and TYK2 by interfering in the JAK-STAT signaling pathway. JAK Inhibitors are used for the treatment purpose in cancer and inflammatory diseases like rheuma...